Background:

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B.

Applications:

WB, IHC

Name of antibody:

MAP3K7(Ab-187)

Immunogen:

Synthesized non-phosphopeptide derived from human MAP3K7 around the phosphorylation site of threonine 187 (H-M-T(p)-N-N).

Full name:

mitogen-activated protein kinase kinase kinase 7

Synonyms：

TAK1; MEKK7; TGF1a

SwissProt:

O43318

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

67 kDa

WB Positive control:

Jurkat cells treated with heat shock lysate

WB Recommended dilution:

500-3000