Background:

This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.

Applications:

WB

Name of antibody:

PTRF

Immunogen:

Synthesized peptide derived from Internal of human PTRF.

Full name:

polymerase I and transcript release factor

Synonyms：

CGL4; CAVIN; CAVIN1; FKSG13; cavin-1

SwissProt:

Q6NZI2

WB Predicted band size:

43 kDa

WB Positive control:

Hela cells and A549 cells lysates

WB Recommended dilution:

500-3000