Background:

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

TLR1

Immunogen:

Fusion protein of human TLR1

Full name:

toll-like receptor 1

Synonyms：

TIL; CD281; rsc786; TIL. LPRS5

SwissProt:

Q15399

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human brain and Human liver cancer

IHC Recommend dilution:

15-50

WB Predicted band size:

90 kDa

WB Positive control:

Mouse thymus tissue and K562 cells

WB Recommended dilution:

200-1000